Transcription factors with Perturb-seq knockdown data for ENSG00000291067. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291067 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291067, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:58,179,409–58,180,032 | 129.7 kb | Distal (>10kb) Multiome | 520 | |
| chr20:58,228,258–58,229,094 | 80.7 kb | Distal (>10kb) Multiome | 184 | |
| chr20:58,308,722–58,310,416 | 259 bp | At TSS Multiome | 732 | |
| chr20:58,331,681–58,332,501 | 22.7 kb | Distal (>10kb) Multiome | 115 | |
| chr20:58,388,753–58,389,913 | 79.7 kb | Distal (>10kb) Multiome | 887 | |
| chr20:58,482,394–58,483,281 | 173.2 kb | Distal (>10kb) Multiome | 155 | |
| chr20:58,514,461–58,515,572 | 205.7 kb | Distal (>10kb) Multiome | 173 | |
| chr20:58,523,004–58,524,066 | 214.0 kb | Distal (>10kb) Multiome | 197 | |
| chr20:58,546,673–58,547,327 | 237.6 kb | Distal (>10kb) Multiome | 69 |
Genomic view of the ENSG00000291067 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.