Transcription factors with Perturb-seq knockdown data for ENSG00000290851. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290851 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290851, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:16,498,731–16,499,831 | 260.0 kb | Distal (>10kb) Multiome | 710 | |
| chr1:16,513,524–16,514,536 | 245.2 kb | Distal (>10kb) Multiome | 716 | |
| chr1:16,534,972–16,535,673 | 224.0 kb | Distal (>10kb) Multiome | 146 | |
| chr1:16,612,236–16,614,194 | 145.7 kb | Distal (>10kb) Multiome | 1105 | |
| chr1:16,620,707–16,621,639 | 138.1 kb | Distal (>10kb) Multiome | 685 | |
| chr1:16,639,254–16,639,764 | 119.8 kb | Distal (>10kb) Multiome | 46 | |
| chr1:16,644,020–16,645,162 | 114.6 kb | Distal (>10kb) Multiome | 979 | |
| chr1:16,727,237–16,727,897 | 31.9 kb | Distal (>10kb) Multiome | 430 | |
| chr1:16,872,473–16,872,975 | 113.4 kb | Distal (>10kb) Multiome | 52 | |
| chr1:16,888,814–16,889,966 | 130.2 kb | Distal (>10kb) Multiome | 224 | |
| chr1:16,895,953–16,897,630 | 137.0 kb | Distal (>10kb) Multiome | 749 | |
| chr1:16,903,833–16,905,921 | 145.8 kb | Distal (>10kb) Multiome | 1065 | |
| chr1:16,913,177–16,914,707 | 154.8 kb | Distal (>10kb) Multiome | 712 | |
| chr1:16,921,360–16,922,846 | 162.5 kb | Distal (>10kb) Multiome | 315 | |
| chr1:16,938,744–16,939,855 | 180.0 kb | Distal (>10kb) Multiome | 81 | |
| chr1:16,960,652–16,961,242 | 201.6 kb | Distal (>10kb) Multiome | 417 | |
| chr1:16,980,463–16,980,871 | 221.3 kb | Distal (>10kb) Multiome | 187 | |
| chr1:17,011,200–17,012,363 | 252.7 kb | Distal (>10kb) Multiome | 573 | |
| chr1:17,053,525–17,054,572 | 294.9 kb | Distal (>10kb) Multiome | 770 |
Genomic view of the ENSG00000290851 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.