Transcription factors with Perturb-seq knockdown data for ENSG00000290581. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290581 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290581, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:14,063,608–14,064,106 | 128.3 kb | Distal (>10kb) Multiome | 52 | |
| chr21:14,102,970–14,103,852 | 167.8 kb | Distal (>10kb) Multiome | 33 | |
| chr21:14,104,142–14,105,280 | 169.2 kb | Distal (>10kb) Multiome | 34 | |
| chr21:14,215,930–14,216,653 | 280.5 kb | Distal (>10kb) Multiome | 324 |
Genomic view of the ENSG00000290581 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.