Transcription factors with Perturb-seq knockdown data for ENSG00000289108. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289108 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289108, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:65,006,175–65,006,968 | 245.7 kb | Distal (>10kb) Multiome | 666 | |
| chr7:65,037,736–65,039,147 | 214.2 kb | Distal (>10kb) Multiome | 335 | |
| chr7:65,080,759–65,081,624 | 171.2 kb | Distal (>10kb) Multiome | 273 | |
| chr7:65,233,376–65,233,924 | 18.7 kb | Distal (>10kb) Multiome | 61 | |
| chr7:65,239,449–65,240,350 | 12.5 kb | Distal (>10kb) Multiome | 420 | |
| chr7:65,251,663–65,252,869 | 116 bp | At TSS Multiome | 690 | |
| chr7:65,260,488–65,261,069 | 8.1 kb | Proximal (<10kb) | 104 | |
| chr7:65,268,929–65,270,162 | 16.9 kb | Distal (>10kb) Multiome | 581 | |
| chr7:65,373,299–65,374,394 | 121.5 kb | Distal (>10kb) Multiome | 738 |
Genomic view of the ENSG00000289108 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.