Transcription factors with Perturb-seq knockdown data for ENSG00000287460. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287460 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287460, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:54,356,208–54,356,764 | 216.0 kb | Distal (>10kb) Multiome | 88 | |
| chr13:54,402,598–54,404,029 | 169.0 kb | Distal (>10kb) Multiome | 191 | |
| chr13:54,572,016–54,572,314 | 39 bp | At TSS | 23 | |
| chr13:54,573,120–54,573,448 | 766 bp | At TSS | 7 | |
| chr13:54,637,270–54,637,734 | 65.2 kb | Distal (>10kb) Multiome | 204 | |
| chr13:54,705,470–54,706,743 | 133.7 kb | Distal (>10kb) Multiome | 201 |
Genomic view of the ENSG00000287460 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.