Transcription factors with Perturb-seq knockdown data for ENSG00000286719. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286719 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286719, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:224,615,699–224,617,266 | 265.2 kb | Distal (>10kb) Multiome | 511 | |
| chr1:224,639,152–224,640,098 | 241.8 kb | Distal (>10kb) Multiome | 68 | |
| chr1:224,700,754–224,701,811 | 180.1 kb | Distal (>10kb) Multiome | 221 | |
| chr1:224,720,167–224,720,687 | 161.0 kb | Distal (>10kb) Multiome | 31 | |
| chr1:224,819,574–224,820,676 | 61.3 kb | Distal (>10kb) Multiome | 133 | |
| chr1:224,839,656–224,840,506 | 41.3 kb | Distal (>10kb) Multiome | 111 | |
| chr1:224,880,598–224,880,888 | 466 bp | At TSS | 71 | |
| chr1:224,929,306–224,930,138 | 48.3 kb | Distal (>10kb) Multiome | 992 |
Genomic view of the ENSG00000286719 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.