Transcription factors with Perturb-seq knockdown data for ENSG00000286467. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286467 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286467, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:133,145,882–133,153,168 | 111.1 kb | Distal (>10kb) Multiome HiCAR | 683 | |
| chr4:133,253,004–133,253,430 | 9.7 kb | Proximal (<10kb) | 80 | |
| chr4:133,261,419–133,261,975 | 1.1 kb | Proximal (<10kb) | 66 | |
| chr4:133,262,656–133,265,239 | at TSS | At TSS | 326 | |
| chr4:133,266,252–133,267,311 | 3.1 kb | Proximal (<10kb) | 61 | |
| chr4:133,267,418–133,269,031 | 5.5 kb | Proximal (<10kb) Multiome | 231 | |
| chr4:133,269,987–133,270,579 | 6.9 kb | Proximal (<10kb) | 47 | |
| chr4:133,275,193–133,275,752 | 12.3 kb | Distal (>10kb) Multiome | 115 |
Genomic view of the ENSG00000286467 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.