Transcription factors with Perturb-seq knockdown data for ENSG00000286161. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286161 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286161, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:52,711,775–52,713,336 | 9.0 kb | Proximal (<10kb) | 936 | |
| chr4:52,716,767–52,717,011 | 5.4 kb | Proximal (<10kb) | 50 | |
| chr4:52,717,160–52,717,485 | 4.9 kb | Proximal (<10kb) | 16 | |
| chr4:52,718,125–52,718,453 | 3.9 kb | Proximal (<10kb) | 46 | |
| chr4:52,721,591–52,722,821 | at TSS | At TSS | 629 |
Genomic view of the ENSG00000286161 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.