Transcription factors with Perturb-seq knockdown data for ENSG00000285283. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000285283 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000285283, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:31,802,527–31,803,248 | 9.1 kb | Proximal (<10kb) | 61 | |
| chr11:31,803,398–31,803,696 | 8.7 kb | Proximal (<10kb) | 41 | |
| chr11:31,804,516–31,806,498 | 5.9 kb | Proximal (<10kb) | 220 | |
| chr11:31,807,374–31,808,054 | 4.3 kb | Proximal (<10kb) | 35 | |
| chr11:31,809,858–31,815,212 | at TSS | At TSS | 719 | |
| chr11:31,815,345–31,815,712 | 3.0 kb | Proximal (<10kb) | 78 | |
| chr11:31,815,841–31,816,162 | 3.5 kb | Proximal (<10kb) | 176 | |
| chr11:31,816,322–31,818,635 | 3.9 kb | Proximal (<10kb) | 399 | |
| chr11:31,818,793–31,819,408 | 6.4 kb | Proximal (<10kb) | 43 | |
| chr11:31,819,537–31,820,941 | 7.1 kb | Proximal (<10kb) | 197 | |
| chr11:31,822,793–31,823,338 | 6.4 kb | Proximal (<10kb) | 55 | |
| chr11:31,823,464–31,824,163 | 7.1 kb | Proximal (<10kb) | 97 | |
| chr11:31,824,867–31,825,385 | 8.5 kb | Proximal (<10kb) | 49 | |
| chr11:31,825,773–31,826,408 | 9.4 kb | Proximal (<10kb) | 114 |
Genomic view of the ENSG00000285283 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.