Transcription factors with Perturb-seq knockdown data for ENSG00000284700. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000284700 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000284700, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:50,415,232–50,416,629 | 7.0 kb | Proximal (<10kb) | 117 | |
| chr1:50,416,739–50,417,464 | 6.1 kb | Proximal (<10kb) | 115 | |
| chr1:50,418,573–50,419,824 | 3.8 kb | Proximal (<10kb) | 250 | |
| chr1:50,420,661–50,421,743 | 1.9 kb | Proximal (<10kb) | 164 | |
| chr1:50,422,450–50,424,285 | at TSS | At TSS | 446 | |
| chr1:50,424,918–50,425,562 | 1.3 kb | Proximal (<10kb) | 78 | |
| chr1:50,425,784–50,425,966 | 2.2 kb | Proximal (<10kb) | 53 | |
| chr1:50,427,164–50,428,267 | 3.6 kb | Proximal (<10kb) | 113 | |
| chr1:50,430,493–50,431,246 | 6.9 kb | Proximal (<10kb) | 96 |
Genomic view of the ENSG00000284700 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.