Transcription factors with Perturb-seq knockdown data for ENSG00000284428. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000284428 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000284428, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:23,074,842–23,075,882 | 198.9 kb | Distal (>10kb) Multiome | 399 | |
| chr19:23,116,566–23,117,541 | 157.2 kb | Distal (>10kb) Multiome | 257 | |
| chr19:23,203,789–23,204,323 | 70.2 kb | Distal (>10kb) Multiome | 53 | |
| chr19:23,249,247–23,251,013 | 23.8 kb | Distal (>10kb) Multiome | 457 | |
| chr19:23,254,024–23,254,900 | 19.7 kb | Distal (>10kb) Multiome | 62 | |
| chr19:23,273,473–23,274,442 | 41 bp | At TSS Multiome | 565 | |
| chr19:23,277,685–23,278,396 | 3.8 kb | Proximal (<10kb) Multiome | 71 | |
| chr19:23,284,033–23,284,221 | 9.8 kb | Proximal (<10kb) | 54 | |
| chr19:23,394,943–23,396,090 | 121.3 kb | Distal (>10kb) Multiome HiCAR | 575 | |
| chr19:23,415,164–23,416,387 | 141.7 kb | Distal (>10kb) Multiome | 222 | |
| chr19:24,033,224–24,034,370 | 759.3 kb | Distal (>10kb) Multiome HiCAR | 673 | |
| chr19:24,086,718–24,087,708 | 813.0 kb | Distal (>10kb) Multiome HiCAR | 390 |
Genomic view of the ENSG00000284428 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.