Transcription factors with Perturb-seq knockdown data for ENSG00000283692. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000283692 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000283692, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:137,352,013–137,352,553 | 221.7 kb | Distal (>10kb) Multiome | 42 | |
| chrX:137,424,537–137,425,314 | 149.1 kb | Distal (>10kb) Multiome | 127 | |
| chrX:137,427,670–137,429,650 | 145.7 kb | Distal (>10kb) Multiome | 213 | |
| chrX:137,429,912–137,430,677 | 143.7 kb | Distal (>10kb) Multiome HiCAR | 45 | |
| chrX:137,430,864–137,431,606 | 142.8 kb | Distal (>10kb) Multiome HiCAR | 45 | |
| chrX:137,563,909–137,564,656 | 9.8 kb | Proximal (<10kb) Multiome | 82 | |
| chrX:137,565,613–137,566,987 | 7.9 kb | Proximal (<10kb) Multiome | 236 | |
| chrX:137,573,672–137,575,319 | 478 bp | At TSS Multiome | 279 | |
| chrX:137,748,706–137,749,618 | 175.1 kb | Distal (>10kb) Multiome HiCAR | 107 | |
| chrX:137,916,058–137,916,631 | 342.3 kb | Distal (>10kb) Multiome HiCAR | 152 |
Genomic view of the ENSG00000283692 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.