Transcription factors with Perturb-seq knockdown data for ENSG00000283415. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000283415 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000283415, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,629,672–6,631,067 | 296.4 kb | Distal (>10kb) Multiome | 226 | |
| chr11:6,655,068–6,656,298 | 271.1 kb | Distal (>10kb) Multiome | 314 | |
| chr11:6,682,693–6,683,793 | 243.4 kb | Distal (>10kb) Multiome | 950 | |
| chr11:6,925,579–6,927,200 | 380 bp | At TSS Multiome | 584 | |
| chr11:6,927,323–6,927,601 | 445 bp | At TSS | 64 | |
| chr11:7,019,692–7,020,997 | 93.6 kb | Distal (>10kb) Multiome | 565 |
Genomic view of the ENSG00000283415 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.