Transcription factors with Perturb-seq knockdown data for ENSG00000275180. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000275180 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000275180, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:62,435,134–62,436,513 | 167.5 kb | Distal (>10kb) Multiome | 442 | |
| chr12:62,466,179–62,467,402 | 136.6 kb | Distal (>10kb) Multiome | 866 | |
| chr12:62,602,250–62,603,979 | 668 bp | At TSS Multiome | 1165 | |
| chr12:62,604,879–62,605,185 | 1.5 kb | Proximal (<10kb) | 93 | |
| chr12:62,606,116–62,606,362 | 2.8 kb | Proximal (<10kb) | 40 | |
| chr12:62,606,578–62,607,129 | 3.2 kb | Proximal (<10kb) | 53 | |
| chr12:62,608,556–62,609,392 | 5.2 kb | Proximal (<10kb) | 34 | |
| chr12:62,609,917–62,610,248 | 6.6 kb | Proximal (<10kb) | 15 | |
| chr12:62,610,632–62,611,303 | 7.3 kb | Proximal (<10kb) | 10 | |
| chr12:62,611,447–62,611,794 | 8.1 kb | Proximal (<10kb) | 3 | |
| chr12:62,611,911–62,612,510 | 8.5 kb | Proximal (<10kb) | 11 | |
| chr12:62,646,389–62,647,205 | 43.4 kb | Distal (>10kb) Multiome | 78 | |
| chr12:62,653,374–62,655,092 | 50.7 kb | Distal (>10kb) Multiome | 290 | |
| chr12:62,673,057–62,673,824 | 70.2 kb | Distal (>10kb) Multiome | 53 | |
| chr12:62,768,586–62,770,424 | 166.9 kb | Distal (>10kb) Multiome HiCAR | 179 | |
| chr12:62,792,786–62,794,262 | 190.1 kb | Distal (>10kb) Multiome HiCAR | 428 |
Genomic view of the ENSG00000275180 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.