Transcription factors with Perturb-seq knockdown data for ENSG00000275155. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000275155 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000275155, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:49,838,622–49,839,188 | 8.4 kb | Proximal (<10kb) | 82 | |
| chr16:49,849,600–49,849,933 | 2.0 kb | Proximal (<10kb) | 34 | |
| chr16:49,853,284–49,853,558 | 5.7 kb | Proximal (<10kb) | 19 | |
| chr16:49,854,387–49,856,396 | 6.8 kb | Proximal (<10kb) | 495 | |
| chr16:49,856,552–49,859,437 | 8.9 kb | Proximal (<10kb) | 535 |
Genomic view of the ENSG00000275155 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.