Transcription factors with Perturb-seq knockdown data for ENSG00000274547. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000274547 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000274547, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:44,928,632–44,930,007 | 8.8 kb | Proximal (<10kb) | 186 | |
| chr2:44,930,118–44,930,479 | 8.4 kb | Proximal (<10kb) | 64 | |
| chr2:44,932,798–44,933,373 | 5.5 kb | Proximal (<10kb) | 62 | |
| chr2:44,934,122–44,936,090 | 2.7 kb | Proximal (<10kb) | 246 | |
| chr2:44,937,044–44,939,675 | at TSS | At TSS | 512 | |
| chr2:44,939,777–44,940,009 | 945 bp | At TSS | 43 | |
| chr2:44,940,953–44,942,676 | 2.1 kb | Proximal (<10kb) | 260 | |
| chr2:44,943,778–44,944,903 | 4.9 kb | Proximal (<10kb) | 119 | |
| chr2:44,945,722–44,946,385 | 6.9 kb | Proximal (<10kb) | 150 |
Genomic view of the ENSG00000274547 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.