Transcription factors with Perturb-seq knockdown data for ENSG00000273325. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000273325 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000273325, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:32,139,785–32,140,267 | 144.6 kb | Distal (>10kb) Multiome | 14 | |
| chr22:32,175,754–32,176,273 | 108.6 kb | Distal (>10kb) Multiome | 106 | |
| chr22:32,202,214–32,203,260 | 82.2 kb | Distal (>10kb) Multiome | 251 | |
| chr22:32,204,184–32,205,469 | 79.7 kb | Distal (>10kb) Multiome | 338 | |
| chr22:32,206,463–32,207,219 | 77.7 kb | Distal (>10kb) Multiome | 136 | |
| chr22:32,474,361–32,475,480 | 190.1 kb | Distal (>10kb) Multiome | 819 | |
| chr22:32,502,334–32,503,331 | 218.0 kb | Distal (>10kb) Multiome | 63 | |
| chr22:32,531,984–32,532,601 | 247.7 kb | Distal (>10kb) Multiome | 610 |
Genomic view of the ENSG00000273325 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.