Transcription factors with Perturb-seq knockdown data for ENSG00000273209. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000273209 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000273209, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:201,780,355–201,781,686 | 252.5 kb | Distal (>10kb) Multiome | 963 | |
| chr2:201,787,334–201,788,076 | 245.8 kb | Distal (>10kb) Multiome | 227 | |
| chr2:201,858,878–201,859,345 | 174.5 kb | Distal (>10kb) Multiome HiCAR | 246 | |
| chr2:201,860,619–201,861,352 | 172.6 kb | Distal (>10kb) Multiome HiCAR | 253 | |
| chr2:201,866,586–201,867,010 | 166.7 kb | Distal (>10kb) Multiome HiCAR | 139 | |
| chr2:201,906,909–201,907,931 | 126.2 kb | Distal (>10kb) Multiome HiCAR | 255 | |
| chr2:201,929,476–201,930,044 | 103.7 kb | Distal (>10kb) Multiome HiCAR | 78 | |
| chr2:201,932,304–201,933,049 | 100.9 kb | Distal (>10kb) Multiome | 131 | |
| chr2:201,948,994–201,950,276 | 84.0 kb | Distal (>10kb) Multiome HiCAR | 334 | |
| chr2:202,019,731–202,020,536 | 13.4 kb | Distal (>10kb) Multiome | 118 | |
| chr2:202,023,052–202,024,286 | 9.9 kb | Proximal (<10kb) Multiome | 272 | |
| chr2:202,031,990–202,032,196 | 1.3 kb | Proximal (<10kb) | 87 | |
| chr2:202,032,848–202,036,232 | 196 bp | At TSS Multiome | 769 | |
| chr2:202,038,976–202,040,047 | 6.2 kb | Proximal (<10kb) Multiome | 233 | |
| chr2:202,148,653–202,149,792 | 115.8 kb | Distal (>10kb) Multiome | 213 | |
| chr2:202,163,899–202,164,942 | 131.0 kb | Distal (>10kb) Multiome HiCAR | 79 | |
| chr2:202,237,794–202,239,082 | 205.0 kb | Distal (>10kb) Multiome | 820 | |
| chr2:202,265,167–202,266,195 | 232.2 kb | Distal (>10kb) Multiome | 931 |
Genomic view of the ENSG00000273209 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.