Transcription factors with Perturb-seq knockdown data for ENSG00000269564. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000269564 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000269564, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:53,520,353–53,521,485 | 266.1 kb | Distal (>10kb) Multiome | 700 | |
| chr19:53,537,348–53,538,212 | 249.1 kb | Distal (>10kb) Multiome | 623 | |
| chr19:53,594,477–53,595,909 | 191.6 kb | Distal (>10kb) Multiome | 262 | |
| chr19:53,772,960–53,773,600 | 13.9 kb | Distal (>10kb) Multiome | 98 | |
| chr19:53,774,097–53,775,097 | 12.3 kb | Distal (>10kb) Multiome | 24 | |
| chr19:53,780,539–53,780,815 | 6.1 kb | Proximal (<10kb) | 30 | |
| chr19:53,792,791–53,793,343 | 6.2 kb | Proximal (<10kb) Multiome | 470 | |
| chr19:53,865,880–53,866,753 | 79.3 kb | Distal (>10kb) Multiome | 532 | |
| chr19:53,866,887–53,869,891 | 80.8 kb | Distal (>10kb) Multiome | 993 | |
| chr19:53,878,918–53,880,011 | 92.6 kb | Distal (>10kb) Multiome | 561 | |
| chr19:53,881,744–53,882,458 | 95.2 kb | Distal (>10kb) Multiome | 435 | |
| chr19:53,889,715–53,890,286 | 103.1 kb | Distal (>10kb) Multiome | 322 | |
| chr19:53,898,176–53,899,412 | 112.0 kb | Distal (>10kb) Multiome | 212 | |
| chr19:53,907,868–53,908,722 | 121.4 kb | Distal (>10kb) Multiome | 276 | |
| chr19:53,941,849–53,943,229 | 155.5 kb | Distal (>10kb) Multiome | 240 | |
| chr19:53,957,309–53,957,858 | 170.6 kb | Distal (>10kb) Multiome | 97 | |
| chr19:53,977,539–53,979,011 | 191.5 kb | Distal (>10kb) Multiome | 412 | |
| chr19:53,979,770–53,982,403 | 194.4 kb | Distal (>10kb) Multiome | 530 | |
| chr19:53,982,560–53,983,015 | 195.9 kb | Distal (>10kb) Multiome | 119 |
Genomic view of the ENSG00000269564 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.