Transcription factors with Perturb-seq knockdown data for ENSG00000262879. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000262879 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000262879, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:46,770,710–46,773,968 | 328.4 kb | Distal (>10kb) Multiome | 1101 | |
| chr17:46,785,507–46,786,271 | 314.3 kb | Distal (>10kb) Multiome | 111 | |
| chr17:46,818,301–46,820,276 | 280.9 kb | Distal (>10kb) Multiome | 471 | |
| chr17:46,820,873–46,822,625 | 277.9 kb | Distal (>10kb) Multiome | 430 | |
| chr17:46,850,945–46,852,297 | 248.8 kb | Distal (>10kb) Multiome | 470 | |
| chr17:46,922,775–46,923,450 | 177.2 kb | Distal (>10kb) Multiome | 986 | |
| chr17:47,067,246–47,067,672 | at TSS | At TSS | 1024 | |
| chr17:47,099,846–47,100,680 | at TSS | At TSS Multiome | 574 | |
| chr17:47,188,797–47,189,938 | 89.1 kb | Distal (>10kb) Multiome | 1050 | |
| chr17:47,253,593–47,254,400 | 153.7 kb | Distal (>10kb) Multiome | 571 | |
| chr17:47,275,398–47,275,943 | 175.4 kb | Distal (>10kb) Multiome | 340 | |
| chr17:47,310,107–47,310,844 | 210.2 kb | Distal (>10kb) Multiome | 92 | |
| chr17:47,323,422–47,324,660 | 223.6 kb | Distal (>10kb) Multiome | 1009 |
Genomic view of the ENSG00000262879 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.