Transcription factors with Perturb-seq knockdown data for ENSG00000259363. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259363 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259363, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:99,564,843–99,566,939 | 242.0 kb | Distal (>10kb) Multiome | 959 | |
| chr15:99,732,722–99,734,404 | 74.4 kb | Distal (>10kb) Multiome | 723 | |
| chr15:99,752,894–99,753,419 | 54.6 kb | Distal (>10kb) Multiome | 105 | |
| chr15:99,983,052–99,984,349 | 175.6 kb | Distal (>10kb) Multiome | 293 |
Genomic view of the ENSG00000259363 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.