Transcription factors with Perturb-seq knockdown data for ENSG00000257386. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000257386 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000257386, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:74,537,322–74,538,432 | 200 bp | At TSS | 890 | |
| chr12:74,538,580–74,538,886 | at TSS | At TSS | 128 | |
| chr12:74,539,305–74,540,076 | 672 bp | At TSS | 124 | |
| chr12:74,540,183–74,540,744 | 1.6 kb | Proximal (<10kb) | 47 | |
| chr12:74,541,189–74,541,399 | 2.6 kb | Proximal (<10kb) | 71 | |
| chr12:74,546,835–74,548,107 | 8.2 kb | Proximal (<10kb) | 71 |
Genomic view of the ENSG00000257386 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.