Transcription factors with Perturb-seq knockdown data for ENSG00000249737. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000249737 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000249737, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:15,499,582–15,501,921 | 928.3 kb | Distal (>10kb) Multiome HiCAR | 468 | |
| chr5:16,178,616–16,180,665 | 249.4 kb | Distal (>10kb) Multiome HiCAR | 507 | |
| chr5:16,229,115–16,230,175 | 198.8 kb | Distal (>10kb) Multiome HiCAR | 207 | |
| chr5:16,378,323–16,379,199 | 49.6 kb | Distal (>10kb) Multiome | 110 | |
| chr5:16,418,459–16,419,085 | 9.4 kb | Proximal (<10kb) | 330 | |
| chr5:16,419,918–16,420,591 | 8.3 kb | Proximal (<10kb) Multiome | 53 | |
| chr5:16,420,709–16,420,866 | 7.7 kb | Proximal (<10kb) | 3 | |
| chr5:16,421,509–16,421,858 | 6.7 kb | Proximal (<10kb) | 19 | |
| chr5:16,425,020–16,425,719 | 2.8 kb | Proximal (<10kb) | 19 | |
| chr5:16,427,501–16,428,635 | at TSS | At TSS | 40 | |
| chr5:16,430,173–16,430,967 | 1.6 kb | Proximal (<10kb) | 43 | |
| chr5:16,465,184–16,466,419 | 37.3 kb | Distal (>10kb) Multiome | 953 | |
| chr5:16,616,186–16,617,558 | 188.3 kb | Distal (>10kb) Multiome | 428 |
Genomic view of the ENSG00000249737 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.