Transcription factors with Perturb-seq knockdown data for ENSG00000243276. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000243276 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000243276, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:117,626,264–117,627,164 | 1184.0 kb | Distal (>10kb) Multiome HiCAR | 68 | |
| chr3:118,772,170–118,773,201 | 38.1 kb | Distal (>10kb) Multiome | 228 | |
| chr3:118,808,559–118,809,118 | 1.7 kb | Proximal (<10kb) | 118 | |
| chr3:118,810,579–118,811,137 | 87 bp | At TSS Multiome | 139 | |
| chr3:118,817,397–118,818,160 | 6.6 kb | Proximal (<10kb) | 210 | |
| chr3:119,034,159–119,035,267 | 224.0 kb | Distal (>10kb) Multiome | 570 |
Genomic view of the ENSG00000243276 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.