Transcription factors with Perturb-seq knockdown data for ENSG00000243004. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000243004 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000243004, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:20,053,213–20,053,692 | 69.5 kb | Distal (>10kb) Multiome | 21 | |
| chr7:20,086,466–20,087,310 | 36.2 kb | Distal (>10kb) Multiome | 54 | |
| chr7:20,116,956–20,117,235 | 5.9 kb | Proximal (<10kb) | 46 | |
| chr7:20,120,210–20,122,603 | 2.2 kb | Proximal (<10kb) Multiome | 276 | |
| chr7:20,122,710–20,124,424 | at TSS | At TSS | 62 | |
| chr7:20,125,703–20,126,837 | 3.2 kb | Proximal (<10kb) Multiome | 167 | |
| chr7:20,129,510–20,129,925 | 6.4 kb | Proximal (<10kb) | 16 | |
| chr7:20,217,098–20,217,914 | 94.4 kb | Distal (>10kb) Multiome | 460 | |
| chr7:20,219,096–20,220,603 | 96.9 kb | Distal (>10kb) Multiome | 899 | |
| chr7:20,329,378–20,332,363 | 208.5 kb | Distal (>10kb) Multiome | 815 |
Genomic view of the ENSG00000243004 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.