Transcription factors with Perturb-seq knockdown data for ENSG00000242798. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000242798 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000242798, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:99,839,578–99,840,069 | 287.3 kb | Distal (>10kb) Multiome | 85 | |
| chr7:99,929,116–99,929,724 | 197.7 kb | Distal (>10kb) Multiome | 300 | |
| chr7:100,015,387–100,016,069 | 111.5 kb | Distal (>10kb) Multiome | 744 | |
| chr7:100,049,441–100,050,060 | 77.3 kb | Distal (>10kb) Multiome | 800 | |
| chr7:100,081,134–100,083,000 | 45.3 kb | Distal (>10kb) Multiome | 1160 | |
| chr7:100,088,454–100,089,460 | 38.1 kb | Distal (>10kb) Multiome | 955 | |
| chr7:100,100,270–100,102,380 | 26.5 kb | Distal (>10kb) Multiome | 1102 | |
| chr7:100,119,029–100,120,415 | 7.6 kb | Proximal (<10kb) Multiome | 954 | |
| chr7:100,126,675–100,128,006 | 88 bp | At TSS Multiome | 919 | |
| chr7:100,131,000–100,131,255 | 3.9 kb | Proximal (<10kb) | 466 | |
| chr7:100,132,734–100,132,902 | 5.6 kb | Proximal (<10kb) | 296 | |
| chr7:100,148,262–100,149,663 | 21.7 kb | Distal (>10kb) Multiome | 846 | |
| chr7:100,158,247–100,159,079 | 31.6 kb | Distal (>10kb) Multiome | 795 | |
| chr7:100,167,090–100,167,783 | 40.3 kb | Distal (>10kb) Multiome | 123 | |
| chr7:100,167,894–100,168,793 | 41.5 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,171,153–100,171,887 | 44.3 kb | Distal (>10kb) Multiome | 233 | |
| chr7:100,176,986–100,178,152 | 50.4 kb | Distal (>10kb) Multiome | 626 | |
| chr7:100,266,531–100,267,045 | 139.6 kb | Distal (>10kb) Multiome | 24 | |
| chr7:100,270,225–100,270,813 | 143.5 kb | Distal (>10kb) Multiome | 103 | |
| chr7:100,271,732–100,272,774 | 145.2 kb | Distal (>10kb) Multiome | 530 | |
| chr7:100,335,652–100,336,470 | 209.0 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 254.9 kb | Distal (>10kb) Multiome | 49 |
Genomic view of the ENSG00000242798 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.