TFs regulating ENSG00000231731 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000231731. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000231731 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000231731

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000231731, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:127,218,704–127,220,652	243.7 kb	Distal (>10kb) Multiome	316
chr2:127,293,716–127,294,914	169.5 kb	Distal (>10kb) Multiome	876
chr2:127,386,971–127,388,844	76.2 kb	Distal (>10kb) Multiome	986
chr2:127,407,631–127,408,983	55.5 kb	Distal (>10kb) Multiome	878
chr2:127,415,703–127,416,595	47.6 kb	Distal (>10kb) Multiome	501
chr2:127,422,503–127,423,812	40.4 kb	Distal (>10kb) Multiome	321
chr2:127,454,026–127,454,198	9.4 kb	Proximal (<10kb)	178
chr2:127,463,310–127,464,007	26 bp	At TSS Multiome	176
chr2:127,525,984–127,528,084	62.9 kb	Distal (>10kb) Multiome	1026
chr2:127,542,311–127,543,476	79.5 kb	Distal (>10kb) Multiome	233
chr2:127,591,279–127,591,967	128.0 kb	Distal (>10kb) Multiome	431
chr2:127,674,653–127,675,849	211.6 kb	Distal (>10kb) Multiome	324
chr2:127,700,417–127,702,395	237.9 kb	Distal (>10kb) Multiome	1115

Genome Browser

Genomic view of the ENSG00000231731 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.