Transcription factors with Perturb-seq knockdown data for ENSG00000227486. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000227486 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000227486, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:55,717,452–55,718,482 | 190.5 kb | Distal (>10kb) Multiome | 579 | |
| chrX:55,868,198–55,868,947 | 39.7 kb | Distal (>10kb) Multiome | 12 | |
| chrX:55,907,981–55,908,492 | 70 bp | At TSS Multiome | 231 | |
| chrX:55,908,650–55,909,218 | 408 bp | At TSS | 110 |
Genomic view of the ENSG00000227486 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.