Transcription factors with Perturb-seq knockdown data for ENSG00000227400. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000227400 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000227400, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:152,761,973–152,763,655 | 830.9 kb | Distal (>10kb) Multiome HiCAR | 196 | |
| chr2:153,476,536–153,479,755 | 114.4 kb | Distal (>10kb) Multiome | 828 | |
| chr2:153,584,336–153,584,546 | 8.7 kb | Proximal (<10kb) | 12 | |
| chr2:153,592,698–153,593,925 | 22 bp | At TSS Multiome | 229 | |
| chr2:153,595,988–153,596,275 | 2.7 kb | Proximal (<10kb) | 37 | |
| chr2:153,870,862–153,873,964 | 278.5 kb | Distal (>10kb) Multiome | 511 |
Genomic view of the ENSG00000227400 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.