Transcription factors with Perturb-seq knockdown data for ENSG00000227279. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000227279 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000227279, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:27,778,865–27,779,744 | 142.3 kb | Distal (>10kb) Multiome | 123 | |
| chr18:27,792,679–27,793,572 | 128.4 kb | Distal (>10kb) Multiome | 155 | |
| chr18:27,921,458–27,921,726 | at TSS | At TSS | 55 | |
| chr18:27,921,831–27,922,687 | 835 bp | At TSS Multiome | 148 | |
| chr18:28,009,472–28,010,385 | 88.3 kb | Distal (>10kb) Multiome | 113 | |
| chr18:28,064,840–28,066,123 | 143.8 kb | Distal (>10kb) Multiome | 285 | |
| chr18:28,107,534–28,108,565 | 186.5 kb | Distal (>10kb) Multiome | 239 | |
| chr18:28,175,149–28,178,989 | 255.6 kb | Distal (>10kb) Multiome | 791 |
Genomic view of the ENSG00000227279 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.