Transcription factors with Perturb-seq knockdown data for ENSG00000226172. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000226172 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000226172, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:118,991,588–118,992,249 | 9.1 kb | Proximal (<10kb) | 27 | |
| chr1:118,993,028–118,993,553 | 7.8 kb | Proximal (<10kb) | 107 | |
| chr1:119,000,157–119,000,831 | 560 bp | At TSS | 66 | |
| chr1:119,001,185–119,001,929 | at TSS | At TSS | 171 | |
| chr1:119,006,484–119,007,307 | 5.1 kb | Proximal (<10kb) | 118 | |
| chr1:119,007,425–119,009,160 | 6.0 kb | Proximal (<10kb) | 247 |
Genomic view of the ENSG00000226172 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.