TFs regulating ENSG00000225339 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000225339. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000225339 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000225339

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000225339, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:34,056,249–34,056,753	192.1 kb	Distal (>10kb) Multiome	192
chr6:34,143,812–34,144,483	104.4 kb	Distal (>10kb) Multiome	304
chr6:34,144,948–34,146,170	102.9 kb	Distal (>10kb) Multiome	310
chr6:34,196,308–34,196,855	52.1 kb	Distal (>10kb) Multiome HiCAR	723
chr6:34,202,245–34,203,164	45.8 kb	Distal (>10kb) Multiome	90
chr6:34,223,440–34,224,542	24.6 kb	Distal (>10kb) Multiome	795
chr6:34,234,536–34,237,980	13.1 kb	Distal (>10kb) Multiome	1100
chr6:34,246,464–34,249,721	1.8 kb	Proximal (<10kb) Multiome	1030
chr6:34,391,718–34,393,315	144.1 kb	Distal (>10kb) Multiome HiCAR	1033
chr6:34,425,555–34,426,314	177.5 kb	Distal (>10kb) Multiome HiCAR	859
chr6:34,465,686–34,466,203	217.4 kb	Distal (>10kb) Multiome	319
chr6:34,527,078–34,527,644	278.8 kb	Distal (>10kb) Multiome	606
chr6:34,531,348–34,532,578	283.4 kb	Distal (>10kb) Multiome	150

Genome Browser

Genomic view of the ENSG00000225339 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.