Transcription factors with Perturb-seq knockdown data for ENSG00000224905. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000224905 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000224905, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:14,027,178–14,027,730 | at TSS | At TSS | 118 | |
| chr21:14,063,608–14,064,106 | 36.6 kb | Distal (>10kb) Multiome | 52 | |
| chr21:14,102,970–14,103,852 | 76.0 kb | Distal (>10kb) Multiome | 33 | |
| chr21:14,104,142–14,105,280 | 77.5 kb | Distal (>10kb) Multiome | 34 | |
| chr21:14,215,930–14,216,653 | 188.8 kb | Distal (>10kb) Multiome | 324 | |
| chr21:14,281,032–14,281,687 | 254.0 kb | Distal (>10kb) Multiome | 37 |
Genomic view of the ENSG00000224905 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.