Transcription factors with Perturb-seq knockdown data for ENSG00000219445. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000219445 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000219445, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:125,256,577–125,256,746 | 7.5 kb | Proximal (<10kb) | 62 | |
| chr7:125,257,212–125,259,693 | 5.0 kb | Proximal (<10kb) Multiome | 319 | |
| chr7:125,262,651–125,263,026 | 1.3 kb | Proximal (<10kb) | 38 | |
| chr7:125,264,093–125,264,967 | at TSS | At TSS | 83 | |
| chr7:125,316,282–125,317,228 | 52.4 kb | Distal (>10kb) Multiome | 161 | |
| chr7:127,251,385–127,254,562 | 1988.8 kb | Distal (>10kb) Multiome HiCAR | 644 |
Genomic view of the ENSG00000219445 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.