Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid; fatty acid elongation, saturated fatty acid; and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ELOVL7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELOVL7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELOVL7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:60,699,432–60,700,719 | 144.2 kb | Distal (>10kb) Multiome | 1005 | |
| chr5:60,797,358–60,798,212 | 46.4 kb | Distal (>10kb) Multiome | 104 | |
| chr5:60,842,618–60,842,766 | 1.5 kb | Proximal (<10kb) | 23 | |
| chr5:60,842,894–60,844,886 | 33 bp | At TSS Multiome | 755 | |
| chr5:60,848,029–60,848,288 | 3.8 kb | Proximal (<10kb) | 12 | |
| chr5:60,852,462–60,853,271 | 8.2 kb | Proximal (<10kb) | 147 | |
| chr5:60,854,444–60,855,160 | 10.5 kb | Distal (>10kb) Multiome | 164 | |
| chr5:60,944,760–60,946,207 | 100.9 kb | Distal (>10kb) Multiome | 759 |
Genomic view of the ELOVL7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.