This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for ELK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:95,942,226–95,943,879 | 251.4 kb | Distal (>10kb) Multiome | 840 | |
| chr12:96,034,637–96,036,352 | 158.7 kb | Distal (>10kb) Multiome | 921 | |
| chr12:96,192,976–96,193,214 | 1.2 kb | Proximal (<10kb) | 28 | |
| chr12:96,193,825–96,194,736 | 25 bp | At TSS Multiome | 537 | |
| chr12:96,194,843–96,195,428 | 469 bp | At TSS | 320 | |
| chr12:96,195,904–96,196,220 | 1.5 kb | Proximal (<10kb) | 232 | |
| chr12:96,201,940–96,202,197 | 7.6 kb | Proximal (<10kb) | 22 | |
| chr12:96,215,259–96,215,740 | 21.1 kb | Distal (>10kb) Multiome | 518 | |
| chr12:96,256,842–96,257,316 | 62.8 kb | Distal (>10kb) Multiome | 52 | |
| chr12:96,372,974–96,373,613 | 178.9 kb | Distal (>10kb) Multiome | 45 | |
| chr12:96,399,206–96,401,284 | 206.1 kb | Distal (>10kb) Multiome | 864 | |
| chr12:96,428,927–96,429,448 | 234.8 kb | Distal (>10kb) Multiome | 179 | |
| chr12:96,489,370–96,490,086 | 295.2 kb | Distal (>10kb) Multiome | 618 |
Genomic view of the ELK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.