The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for EIF3K. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF3K upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF3K, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:38,319,279–38,320,342 | 299.3 kb | Distal (>10kb) Multiome | 359 | |
| chr19:38,335,358–38,337,514 | 283.4 kb | Distal (>10kb) Multiome | 898 | |
| chr19:38,361,454–38,362,809 | 257.1 kb | Distal (>10kb) Multiome | 604 | |
| chr19:38,374,176–38,375,269 | 244.5 kb | Distal (>10kb) Multiome | 1041 | |
| chr19:38,385,485–38,386,937 | 233.2 kb | Distal (>10kb) Multiome | 156 | |
| chr19:38,387,065–38,389,471 | 231.1 kb | Distal (>10kb) Multiome | 591 | |
| chr19:38,394,369–38,395,035 | 224.5 kb | Distal (>10kb) Multiome | 191 | |
| chr19:38,402,504–38,403,738 | 216.1 kb | Distal (>10kb) Multiome | 940 | |
| chr19:38,417,766–38,418,568 | 201.1 kb | Distal (>10kb) Multiome | 407 | |
| chr19:38,434,539–38,435,128 | 184.3 kb | Distal (>10kb) Multiome | 238 | |
| chr19:38,452,620–38,453,510 | 166.0 kb | Distal (>10kb) Multiome | 355 | |
| chr19:38,506,710–38,507,745 | 111.9 kb | Distal (>10kb) Multiome | 369 | |
| chr19:38,514,956–38,515,568 | 103.9 kb | Distal (>10kb) Multiome | 404 | |
| chr19:38,565,090–38,565,701 | 53.8 kb | Distal (>10kb) Multiome | 164 | |
| chr19:38,595,857–38,597,322 | 22.8 kb | Distal (>10kb) Multiome | 478 | |
| chr19:38,617,752–38,619,569 | 170 bp | At TSS Multiome | 835 | |
| chr19:38,622,158–38,622,847 | 3.0 kb | Proximal (<10kb) | 35 | |
| chr19:38,647,137–38,648,653 | 28.4 kb | Distal (>10kb) Multiome | 856 | |
| chr19:38,666,103–38,666,668 | 47.1 kb | Distal (>10kb) Multiome | 317 | |
| chr19:38,683,677–38,684,144 | 64.5 kb | Distal (>10kb) Multiome | 678 | |
| chr19:38,734,491–38,735,702 | 116.2 kb | Distal (>10kb) Multiome | 338 | |
| chr19:38,735,981–38,737,634 | 117.8 kb | Distal (>10kb) Multiome | 493 | |
| chr19:38,754,913–38,755,455 | 136.0 kb | Distal (>10kb) Multiome | 12 | |
| chr19:38,831,191–38,832,119 | 212.7 kb | Distal (>10kb) Multiome | 931 | |
| chr19:38,849,166–38,852,789 | 232.9 kb | Distal (>10kb) Multiome | 1139 | |
| chr19:38,869,729–38,870,536 | 250.9 kb | Distal (>10kb) Multiome | 350 | |
| chr19:38,899,267–38,900,530 | 280.7 kb | Distal (>10kb) Multiome | 886 |
Genomic view of the EIF3K locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.