This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for EIF2AK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF2AK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF2AK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:39,782,369–39,782,987 | 151.4 kb | Distal (>10kb) Multiome HiCAR | 737 | |
| chr15:39,844,965–39,845,763 | 88.7 kb | Distal (>10kb) Multiome | 26 | |
| chr15:39,888,792–39,889,226 | 45.1 kb | Distal (>10kb) Multiome | 62 | |
| chr15:39,920,609–39,921,284 | 13.2 kb | Distal (>10kb) Multiome | 707 | |
| chr15:39,933,904–39,934,437 | 1 bp | At TSS Multiome | 698 | |
| chr15:40,038,862–40,039,388 | 105.1 kb | Distal (>10kb) Multiome | 750 | |
| chr15:40,108,639–40,109,491 | 174.9 kb | Distal (>10kb) Multiome | 798 | |
| chr15:40,160,791–40,161,326 | 226.9 kb | Distal (>10kb) Multiome | 762 |
Genomic view of the EIF2AK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.