This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for EI24. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EI24 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EI24, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:125,330,306–125,331,087 | 238.7 kb | Distal (>10kb) Multiome | 104 | |
| chr11:125,369,857–125,372,110 | 199.2 kb | Distal (>10kb) Multiome | 226 | |
| chr11:125,404,667–125,405,169 | 164.5 kb | Distal (>10kb) Multiome | 273 | |
| chr11:125,433,337–125,433,944 | 135.8 kb | Distal (>10kb) Multiome | 170 | |
| chr11:125,443,557–125,444,361 | 125.5 kb | Distal (>10kb) Multiome | 142 | |
| chr11:125,495,125–125,496,641 | 73.2 kb | Distal (>10kb) Multiome | 422 | |
| chr11:125,505,583–125,506,532 | 63.5 kb | Distal (>10kb) Multiome | 40 | |
| chr11:125,509,289–125,509,972 | 59.9 kb | Distal (>10kb) Multiome | 165 | |
| chr11:125,568,984–125,569,972 | 70 bp | At TSS Multiome | 796 | |
| chr11:125,591,812–125,593,372 | 23.2 kb | Distal (>10kb) Multiome | 902 | |
| chr11:125,625,323–125,626,856 | 56.6 kb | Distal (>10kb) Multiome | 1108 |
Genomic view of the EI24 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.