Predicted to enable nucleic acid binding activity. Involved in several processes, including cytosolic transport; endocytic recycling; and protein homooligomerization. Acts upstream of or within protein localization to plasma membrane and regulation of cardiac muscle cell membrane potential. Located in ciliary pocket membrane and recycling endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EHD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EHD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EHD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:30,191,616–30,192,270 | 1042.2 kb | Distal (>10kb) Multiome HiCAR | 256 | |
| chr2:31,137,175–31,139,011 | 95.6 kb | Distal (>10kb) Multiome | 503 | |
| chr2:31,207,685–31,208,268 | 26.2 kb | Distal (>10kb) Multiome | 98 | |
| chr2:31,233,770–31,234,931 | 105 bp | At TSS Multiome | 532 | |
| chr2:31,299,050–31,300,156 | 65.6 kb | Distal (>10kb) Multiome | 82 | |
| chr2:31,328,845–31,329,699 | 95.1 kb | Distal (>10kb) Multiome HiCAR | 134 | |
| chr2:31,489,255–31,489,920 | 255.4 kb | Distal (>10kb) Multiome | 119 | |
| chr2:31,496,308–31,497,206 | 262.6 kb | Distal (>10kb) Multiome | 122 |
Genomic view of the EHD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.