Predicted to enable calcium ion binding activity and glycosaminoglycan binding activity. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Part of cell surface. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EGFLAM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EGFLAM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EGFLAM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:38,104,407–38,104,997 | 154.0 kb | Distal (>10kb) Multiome | 299 | |
| chr5:38,256,670–38,257,042 | 1.6 kb | Proximal (<10kb) | 36 | |
| chr5:38,257,138–38,259,418 | 683 bp | At TSS Multiome | 516 | |
| chr5:38,265,446–38,266,067 | 6.8 kb | Proximal (<10kb) | 244 | |
| chr5:38,339,209–38,340,222 | 80.9 kb | Distal (>10kb) Multiome | 116 | |
| chr5:38,340,677–38,342,767 | 83.8 kb | Distal (>10kb) Multiome | 137 | |
| chr5:38,367,348–38,368,809 | 108.9 kb | Distal (>10kb) Multiome | 123 | |
| chr5:38,378,926–38,379,942 | 120.9 kb | Distal (>10kb) Multiome | 246 | |
| chr5:38,431,142–38,431,961 | 172.9 kb | Distal (>10kb) Multiome | 118 | |
| chr5:38,472,623–38,473,502 | 214.5 kb | Distal (>10kb) Multiome | 153 | |
| chr5:38,555,925–38,557,581 | 298.1 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the EGFLAM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.