Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EFCAB11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EFCAB11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EFCAB11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:89,026,793–89,028,061 | 927.3 kb | Distal (>10kb) Multiome HiCAR | 495 | |
| chr14:89,040,230–89,041,239 | 914.1 kb | Distal (>10kb) Multiome HiCAR | 745 | |
| chr14:89,293,361–89,294,256 | 661.0 kb | Distal (>10kb) Multiome HiCAR | 120 | |
| chr14:89,296,358–89,297,002 | 658.2 kb | Distal (>10kb) Multiome HiCAR | 136 | |
| chr14:89,701,135–89,702,212 | 253.0 kb | Distal (>10kb) Multiome | 549 | |
| chr14:89,773,515–89,774,088 | 180.9 kb | Distal (>10kb) Multiome | 357 | |
| chr14:89,911,311–89,911,904 | 43.1 kb | Distal (>10kb) Multiome | 338 | |
| chr14:89,954,246–89,956,690 | 1.3 kb | Proximal (<10kb) Multiome | 1046 | |
| chr14:89,960,989–89,961,253 | 6.3 kb | Proximal (<10kb) | 20 | |
| chr14:90,060,116–90,062,635 | 105.9 kb | Distal (>10kb) Multiome | 531 | |
| chr14:90,204,480–90,205,107 | 250.0 kb | Distal (>10kb) Multiome | 34 | |
| chr14:90,235,195–90,235,657 | 280.7 kb | Distal (>10kb) Multiome | 401 |
Genomic view of the EFCAB11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.