Predicted to enable DNA binding activity and catalytic activity. Involved in positive regulation of cholesterol efflux. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EEPD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEPD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEPD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:36,045,836–36,046,420 | 107.1 kb | Distal (>10kb) Multiome HiCAR | 89 | |
| chr7:36,049,505–36,050,356 | 103.4 kb | Distal (>10kb) Multiome HiCAR | 15 | |
| chr7:36,084,466–36,085,311 | 68.5 kb | Distal (>10kb) Multiome HiCAR | 475 | |
| chr7:36,112,818–36,113,397 | 40.1 kb | Distal (>10kb) Multiome HiCAR | 87 | |
| chr7:36,152,317–36,154,017 | 310 bp | At TSS Multiome HiCAR | 781 | |
| chr7:36,154,115–36,154,728 | 862 bp | At TSS | 148 | |
| chr7:36,158,155–36,158,528 | 4.9 kb | Proximal (<10kb) | 54 | |
| chr7:36,258,280–36,258,762 | 105.4 kb | Distal (>10kb) Multiome HiCAR | 236 | |
| chr7:36,278,017–36,278,924 | 125.1 kb | Distal (>10kb) Multiome HiCAR | 133 | |
| chr7:36,280,728–36,281,576 | 128.0 kb | Distal (>10kb) Multiome HiCAR | 293 | |
| chr7:36,317,138–36,318,414 | 164.3 kb | Distal (>10kb) Multiome HiCAR | 28 | |
| chr7:36,366,649–36,367,847 | 214.0 kb | Distal (>10kb) Multiome | 792 | |
| chr7:36,388,932–36,390,769 | 236.6 kb | Distal (>10kb) Multiome | 1029 |
Genomic view of the EEPD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.