This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EEF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:3,699,968–3,700,899 | 281.8 kb | Distal (>10kb) Multiome | 489 | |
| chr19:3,721,462–3,721,997 | 260.7 kb | Distal (>10kb) Multiome | 760 | |
| chr19:3,722,652–3,723,093 | 259.3 kb | Distal (>10kb) Multiome | 106 | |
| chr19:3,761,103–3,762,150 | 220.7 kb | Distal (>10kb) Multiome | 839 | |
| chr19:3,762,300–3,763,344 | 219.4 kb | Distal (>10kb) Multiome | 817 | |
| chr19:3,786,012–3,786,456 | 196.1 kb | Distal (>10kb) Multiome | 237 | |
| chr19:3,868,451–3,869,181 | 113.3 kb | Distal (>10kb) Multiome | 233 | |
| chr19:3,932,937–3,933,664 | 49.0 kb | Distal (>10kb) Multiome | 198 | |
| chr19:3,968,623–3,969,280 | 13.5 kb | Distal (>10kb) Multiome | 547 | |
| chr19:3,970,535–3,971,713 | 11.1 kb | Distal (>10kb) Multiome | 728 | |
| chr19:3,985,032–3,985,862 | 3.1 kb | Proximal (<10kb) Multiome | 932 | |
| chr19:3,986,798–3,987,324 | 4.5 kb | Proximal (<10kb) | 193 | |
| chr19:3,987,682–3,988,217 | 5.7 kb | Proximal (<10kb) Multiome | 346 | |
| chr19:3,990,254–3,990,475 | 7.9 kb | Proximal (<10kb) | 355 | |
| chr19:4,006,992–4,008,553 | 25.2 kb | Distal (>10kb) Multiome | 888 | |
| chr19:4,064,058–4,067,782 | 83.6 kb | Distal (>10kb) Multiome | 811 | |
| chr19:4,123,681–4,124,581 | 141.9 kb | Distal (>10kb) Multiome | 798 | |
| chr19:4,182,102–4,182,890 | 200.2 kb | Distal (>10kb) Multiome | 862 | |
| chr19:4,198,066–4,198,600 | 216.0 kb | Distal (>10kb) Multiome | 214 | |
| chr19:4,246,623–4,247,617 | 265.0 kb | Distal (>10kb) Multiome | 960 |
Genomic view of the EEF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.