This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for DYRK1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYRK1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYRK1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:39,539,469–39,540,414 | 294.0 kb | Distal (>10kb) Multiome | 772 | |
| chr19:39,793,033–39,793,501 | 40.9 kb | Distal (>10kb) Multiome | 418 | |
| chr19:39,824,152–39,825,056 | 9.5 kb | Proximal (<10kb) Multiome | 531 | |
| chr19:39,833,207–39,834,766 | 332 bp | At TSS Multiome | 779 | |
| chr19:39,845,668–39,847,301 | 12.2 kb | Distal (>10kb) Multiome | 854 | |
| chr19:39,970,370–39,971,611 | 136.9 kb | Distal (>10kb) Multiome | 930 | |
| chr19:39,996,681–39,997,502 | 162.9 kb | Distal (>10kb) Multiome | 898 | |
| chr19:40,055,898–40,056,369 | 222.0 kb | Distal (>10kb) Multiome | 746 | |
| chr19:40,090,491–40,091,099 | 256.7 kb | Distal (>10kb) Multiome | 831 |
Genomic view of the DYRK1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.