This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DYRK1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYRK1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYRK1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:37,072,329–37,074,488 | 293.7 kb | Distal (>10kb) Multiome | 994 | |
| chr21:37,220,678–37,221,494 | 145.6 kb | Distal (>10kb) Multiome | 881 | |
| chr21:37,257,305–37,258,840 | 108.6 kb | Distal (>10kb) Multiome | 787 | |
| chr21:37,266,801–37,268,388 | 99.2 kb | Distal (>10kb) Multiome | 1079 | |
| chr21:37,365,724–37,368,330 | 282 bp | At TSS Multiome | 938 | |
| chr21:37,563,444–37,565,351 | 197.2 kb | Distal (>10kb) Multiome | 839 | |
| chr21:37,591,941–37,593,603 | 226.4 kb | Distal (>10kb) Multiome | 223 |
Genomic view of the DYRK1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.