This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DVL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DVL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DVL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:183,883,494–183,884,017 | 271.8 kb | Distal (>10kb) Multiome | 83 | |
| chr3:183,884,110–183,885,311 | 270.4 kb | Distal (>10kb) Multiome | 972 | |
| chr3:183,912,940–183,913,709 | 242.1 kb | Distal (>10kb) Multiome | 225 | |
| chr3:184,017,103–184,018,456 | 137.5 kb | Distal (>10kb) Multiome | 878 | |
| chr3:184,134,086–184,134,568 | 21.2 kb | Distal (>10kb) Multiome | 732 | |
| chr3:184,134,801–184,135,887 | 20.0 kb | Distal (>10kb) Multiome | 941 | |
| chr3:184,145,325–184,145,518 | 9.9 kb | Proximal (<10kb) | 170 | |
| chr3:184,154,967–184,155,880 | 56 bp | At TSS Multiome | 580 | |
| chr3:184,174,432–184,175,524 | 19.4 kb | Distal (>10kb) Multiome | 765 | |
| chr3:184,176,129–184,177,706 | 21.3 kb | Distal (>10kb) Multiome | 480 | |
| chr3:184,185,411–184,187,065 | 30.6 kb | Distal (>10kb) Multiome | 878 | |
| chr3:184,229,229–184,229,859 | 74.1 kb | Distal (>10kb) Multiome | 409 | |
| chr3:184,236,026–184,236,474 | 80.8 kb | Distal (>10kb) Multiome | 41 | |
| chr3:184,241,140–184,242,189 | 86.4 kb | Distal (>10kb) Multiome HiCAR | 700 | |
| chr3:184,248,652–184,250,567 | 94.3 kb | Distal (>10kb) Multiome | 1061 | |
| chr3:184,259,723–184,260,497 | 104.7 kb | Distal (>10kb) Multiome | 318 | |
| chr3:184,260,815–184,262,571 | 106.3 kb | Distal (>10kb) Multiome | 511 | |
| chr3:184,298,591–184,299,718 | 143.7 kb | Distal (>10kb) Multiome | 768 | |
| chr3:184,314,169–184,315,514 | 159.2 kb | Distal (>10kb) Multiome | 761 | |
| chr3:184,335,265–184,337,276 | 180.6 kb | Distal (>10kb) Multiome | 796 | |
| chr3:184,338,471–184,338,964 | 183.3 kb | Distal (>10kb) Multiome | 203 | |
| chr3:184,361,172–184,363,709 | 207.9 kb | Distal (>10kb) Multiome | 1034 | |
| chr3:184,379,849–184,380,935 | 224.8 kb | Distal (>10kb) Multiome | 242 |
Genomic view of the DVL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.