Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DTL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DTL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DTL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:211,667,030–211,667,875 | 368.3 kb | Distal (>10kb) Multiome HiCAR | 301 | |
| chr1:211,675,193–211,676,330 | 360.0 kb | Distal (>10kb) Multiome HiCAR | 936 | |
| chr1:211,695,364–211,695,890 | 340.0 kb | Distal (>10kb) Multiome HiCAR | 283 | |
| chr1:211,698,066–211,699,596 | 337.1 kb | Distal (>10kb) Multiome HiCAR | 651 | |
| chr1:211,829,926–211,831,171 | 205.0 kb | Distal (>10kb) Multiome | 682 | |
| chr1:211,889,249–211,890,017 | 146.1 kb | Distal (>10kb) Multiome | 139 | |
| chr1:211,895,246–211,895,795 | 140.2 kb | Distal (>10kb) Multiome | 267 | |
| chr1:212,034,569–212,036,407 | 291 bp | At TSS Multiome | 995 | |
| chr1:212,044,920–212,045,344 | 9.2 kb | Proximal (<10kb) | 12 | |
| chr1:212,214,185–212,214,767 | 178.9 kb | Distal (>10kb) Multiome | 99 | |
| chr1:212,284,406–212,286,816 | 249.4 kb | Distal (>10kb) Multiome | 1049 | |
| chr1:212,309,881–212,310,794 | 274.5 kb | Distal (>10kb) Multiome HiCAR | 183 | |
| chr1:212,315,914–212,316,445 | 280.4 kb | Distal (>10kb) Multiome HiCAR | 140 | |
| chr1:212,413,972–212,416,004 | 379.2 kb | Distal (>10kb) Multiome HiCAR | 833 |
Genomic view of the DTL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.