The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for DSCAML1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DSCAML1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DSCAML1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:117,410,817–117,412,004 | 385.9 kb | Distal (>10kb) Multiome HiCAR | 247 | |
| chr11:117,429,727–117,430,361 | 367.1 kb | Distal (>10kb) Multiome HiCAR | 126 | |
| chr11:117,443,412–117,443,876 | 353.5 kb | Distal (>10kb) Multiome HiCAR | 185 | |
| chr11:117,551,878–117,552,889 | 244.9 kb | Distal (>10kb) Multiome | 100 | |
| chr11:117,796,174–117,796,636 | 579 bp | At TSS | 111 | |
| chr11:117,796,801–117,797,495 | at TSS | At TSS | 162 | |
| chr11:117,807,579–117,807,749 | 9.8 kb | Proximal (<10kb) | 142 | |
| chr11:117,809,206–117,809,579 | 7.9 kb | Proximal (<10kb) | 286 | |
| chr11:117,814,716–117,815,120 | 2.4 kb | Proximal (<10kb) | 258 | |
| chr11:117,816,221–117,816,726 | 798 bp | At TSS | 282 | |
| chr11:117,816,894–117,818,195 | 20.6 kb | Distal (>10kb) Multiome | 420 | |
| chr11:117,819,172–117,819,397 | 1.6 kb | Proximal (<10kb) | 150 | |
| chr11:117,876,319–117,877,092 | 79.5 kb | Distal (>10kb) Multiome | 258 | |
| chr11:117,907,190–117,907,664 | 110.2 kb | Distal (>10kb) Multiome | 334 | |
| chr11:117,985,878–117,986,675 | 189.1 kb | Distal (>10kb) Multiome | 594 |
Genomic view of the DSCAML1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.