Enables cadherin binding activity. Predicted to be involved in positive regulation of GTPase activity and regulation of Rho protein signal transduction. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DOCK9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOCK9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOCK9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:98,910,553–98,911,168 | 175.8 kb | Distal (>10kb) Multiome | 216 | |
| chr13:98,975,772–98,976,629 | 110.5 kb | Distal (>10kb) Multiome | 290 | |
| chr13:99,085,956–99,088,407 | 1.2 kb | Proximal (<10kb) Multiome | 739 | |
| chr13:99,200,084–99,202,015 | 114.1 kb | Distal (>10kb) Multiome | 952 | |
| chr13:99,204,975–99,205,472 | 118.6 kb | Distal (>10kb) Multiome | 88 | |
| chr13:99,307,801–99,308,401 | 221.4 kb | Distal (>10kb) Multiome | 300 |
Genomic view of the DOCK9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.